Succinic Acid and Rh Collagen synergize to activate fibroblasts,
enhance extracellular matrix density, deliver a natural lifting and contouring effect.
Dual collagen stimulation (Type I & III) strengthens skin structure,
while PN and HA restore elasticity, visibly reducing stretch marks and sagging
By restoring dermal structure and improving fibroblast activity, pores appear
minimized and skin texture becomes smoother and more uniform.
Combination of Collagen Type I & III and PN enhances extracellular
matrix organization, improving density, resilience, and elasticity for long-term results.
Succinic Acid and NAD+ defend against oxidative stress, slowing down
aging processes and protecting skin from external damage.
Hyaluronic Acid provides long-lasting hydration, while NAD+ energizes cells
and improves metabolism, revitalizing tired, dull skin with youthful glow.
Polynucleotides stimulate tissue regeneration, supporting scar remodeling
and improving overall texture and tone.
Rh Collagen fibers rebuild dermal structure, while Polynucleotides repair and restore tissue,
effectively reducing wrinkles and fine lines for a smoother, firmer appearance.
Recombinant Human Collagen (Rh Collagen) is a new generation of collagen produced through advanced biotechnology.
Unlike older collagen products of animal origin, Rh Collagen is created using recombinant techniques that replicate
the exact amino acid sequence of human collagen, achieving 99.9% similarity to natural collagen in the skin.
This process ensures a safe, pure, and consistent ingredient with no risk of allergic reactions or transmission of animalrelated diseases.
Rh Collagen is highly biocompatible, integrates seamlessly into human tissues, and directly stimulates fibroblasts.
Identify the Collagen Gene
The DNA sequence of human collagen (Type I or III) is selected as the target.
Create Recombinant DNA
The collagen gene is combined with a vector (DNA carrier), forming recombinant DNA.
Insert into Host Cells
The recombinant DNA is placed into production system (e.g., bacteria such as E. coli), enabling mass expression of collagen protein.
Create Recombinant DNA
The host cells multiply in culture, continuously producing collagen protein.
Create Recombinant DNA
The protein is extracted, refined, and purified into pure recombinant human collagen(Rh Collagen).
It is the first filler to provide both Type I and Type III recombinant collagen, offering a more complete regeneration process. In simple terms:
Type I builds the framework; Type III keeps it flexible. Together, they restore the skin’s natural balance.
In addition to the fundamental benefits of Rh Collagen Type I & III, Proluma Rh Collagen® is enriched with four powerful bioactive ingredients. These actives work in synergy with collagen to address multiple aging pathways — from energy loss and oxidative stress to dehydration and impaired tissue repair
Together, they enhance fibroblast activity, restore skin vitality, and complement collagen’s structural effect, delivering results that are natural, safe, and long-lasting.
Succinic Acid is a powerful dicarboxylic acid naturally involved
in the Krebs cycle, improving cellular metabolism and oxygenation.
NAD+ is a coenzyme essential for cellular energy and repair.
Its levels decline with age, leading to reduced skin vitality.
Polynucleotides are biopolymers derived from natural DNA fragments
with strong regenerative properties.
A key extracellular matrix component, Hyaluronic Acid provides structural
hydration and creates a favorable environment for fibroblast activity.
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